What's New

The MAL has launched a study entitled “EMG modules as a novel biomarker of basal ganglia plasticity in Parkinson’s disease”. The study funded by the Michael J. Fox Foundation aims to identify specific characteristics of muscle activity that could be linked to changes within the brain that are associated with Parkinson’s disease.

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Susan Regan
(617) 952-6204

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Research

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A Wearable Sensor Platform for the Long-Term Monitoring of Parkinson’s Patients

Our team is working on the development of a wearable sensor system for long-term remote monitoring of patients with Parkinson’s disease (PD). The main motor features of PD are tremor, bradykinesia, rigidity, and impairment of postural balance. Current therapies are effective in managing Parkinsonian symptoms in the early stages of the disease. However, in late stage PD, patients develop motor complications, namely the abrupt loss of the efficacy of medications at the end of a dosing interval and involuntary hyperkinetic movements referred to as dyskinesia. Monitoring changes in the severity of symptoms and motor complications could facilitate the titration of medications, an aspect of the clinical management of patients with PD that becomes challenging as the disease progresses. We hope to address this issue by developing a wearable system to collect data from patients with PD. At the moment, we are developing data analysis techniques to extract UPDRS clinical scores from data recorded using wearable sensors. These techniques will allow tracking of longitudinal changes in motor symptoms in PD patients allowing clinicians to provide more fine tuned therapeutic interventions and improve patient’s quality of life.