Robotic gait training in people with primary lateral sclerosis
Primary lateral sclerosis (PLS) is a rare, degenerative neurological disorder. PLS is uncurable, has an unknown cause, and results in progressive upper motor neuron dysfunction which leads to spasticity.
We are investigating the suitability of the Lokomat device for training people with PLS. Based on evidence from research in other diseases that involve upper motor neuron dysfunction, we anticipate that gait training with Lomokat, a driven gait orthosis device, will produce improvements in speed, endurance and coordination of gait and improve functional capability during walking.
Currently, there is a complete lack of research about rehabilitative interventions for people with PLS. Because difficulty walking is clearly a major cause of morbidity in this population, interventions aimed at improving walking have the potential to make a significant impact on disease burden and quality of life.