What's New

The MAL has launched a study entitled “EMG modules as a novel biomarker of basal ganglia plasticity in Parkinson’s disease”. The study funded by the Michael J. Fox Foundation aims to identify specific characteristics of muscle activity that could be linked to changes within the brain that are associated with Parkinson’s disease.

Contact Us

300 First Avenue 3rd Floor, Room 3297
Charlestown, MA 02129

For Clinical Appointments & Referrals:
Susan Regan
(617) 952-6204

For Research Study Information:
Call our Volunteer Registry Line at
(617) 952-6331


Return to Listing

Robotic gait training in people with primary lateral sclerosis

Primary lateral sclerosis (PLS) is a rare, degenerative neurological disorder.  PLS is uncurable, has an unknown cause, and results in progressive upper motor neuron dysfunction which leads to spasticity.

We are investigating the suitability of the Lokomat device for training people with PLS.  Based on evidence from research in other diseases that involve upper motor neuron dysfunction, we anticipate that gait training with Lomokat, a driven gait orthosis device, will produce improvements in speed, endurance and coordination of gait and improve functional capability during walking.

Currently, there is a complete lack of research about rehabilitative interventions for people with PLS.  Because difficulty walking is clearly a major cause of morbidity in this population, interventions aimed at improving walking have the potential to make a significant impact on disease burden and quality of life.