What's New

The MAL has launched a study entitled “EMG modules as a novel biomarker of basal ganglia plasticity in Parkinson’s disease”. The study funded by the Michael J. Fox Foundation aims to identify specific characteristics of muscle activity that could be linked to changes within the brain that are associated with Parkinson’s disease.

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300 First Avenue 3rd Floor, Room 3297
Charlestown, MA 02129

For Clinical Appointments & Referrals:
Susan Regan
(617) 952-6204

For Research Study Information:
Call our Volunteer Registry Line at
(617) 952-6331


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Past Research Projects

Check out our previous research projects!

Robotic gait training in people with primary lateral sclerosis

Primary lateral sclerosis (PLS) is a rare, degenerative neurological disorder.  PLS is uncurable, has an unknown cause, and results in progressive upper motor neuron dysfunction which leads to spasticity. We are investigating the suitability of the Lokomat device for training people with PLS.  Based on evidence from research in other diseases that involve upper motor [...]

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Wrist Worn Sensors

Stroke is the leading cause of severe long-term disability in the United States, affecting more than 635,000 people in a year alone.  Often with stroke, comes the debilitating loss of motor control that is often more pronounced in one limb than the other. With this loss, patients tend to stop using their affected limb and [...]

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Effects of Robotic Exoskeleton on Bone and General health in Complete Spinal Cord Injury

Spinal cord injuries (SCI) are associated with an accelerated bone loss that occurs primarily at regions below the neurological lesion. The extent of bone loss depends on the severity of motor impairment and individual with motor complete lesions tend to experience more bone loss than those with motor incomplete lesions. The rate of bone loss [...]

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The Effect of Transcranial Direct Current Stimulation Combined with Upper-Extremity Training in a Virtual Environment in Chronic Stroke Survivors

Stroke is a major cause of disability. There are approximately 730,300 new cases in the United States annually. Limited motor recovery in the paretic upper limb accounts for a large proportion of the disabling sequelae. Only about 15% of those with initial complete upper-limb paralysis after stroke recover functional use of their impaired arm in [...]

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A Wearable Sensor Platform for the Long-Term Monitoring of Parkinson’s Patients

Our team is working on the development of a wearable sensor system for long-term remote monitoring of patients with Parkinson’s disease (PD). The main motor features of PD are tremor, bradykinesia, rigidity, and impairment of postural balance. Current therapies are effective in managing Parkinsonian symptoms in the early stages of the disease. However, in late [...]

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A Wearable Sensor Platform for Long-term Home Monitoring of Knee Function

Our aim is to develop a simple, low-cost and wireless wearable device for long-term home monitoring of knee function. The device consists of a sensor platform, a knee attachment with a potentiometer (marked by a yellow circle in the picture above) and a knee sleeve with an e-textile compliance sensor. We chose the Shimmer sensor [...]

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Assessing the eLEGS Powered Exoskeleton for Individuals with Spinal Cord Injury

The eLEGS powered exoskeleton is a device that helps those who have complete or incomplete weakness of both legs after a spinal cord injury, to walk over the ground, to stand and to sit. Ekso Bionics (formerly Berkeley Bionics) has developed this device for use in the rehabilitation setting. The purpose of this study is [...]

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The Effect of Weight Support in Muscle Synergies During Upper Arm Movements in Healthy Subjects

Weight support systems are usually used in rehabilitation of upper limbs in neurological patients but the influence of gravity compensation on upper limb muscle activation and in the reorganization of motor control is unclear. Our aim was to study the effect of weight support on muscle activity during upper arm reaching movements in healthy subjects. [...]

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Estimating Patient’s Anatomical Joint Angles with ARMEO Spring

The ArmeoSpring system is an ergonomic arm exoskeleton with six instrumented revolute joints used to track the movement of the human arm. The exoskeleton provides arm weight support using two springs whose length can be adjusted using lead-screw sliders. One spring is used to unload the upper arm and one is used to unload the [...]

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A Touchscreen System for Rehabilitation of Children with Cerebral Palsy

Cerebral palsy is an umbrella term encompassing a group of non-progressive motor conditions caused by disturbances to the developing brain, causing an impairment in motor function. Traditionally, therapy for children with cerebral palsy involves a child performing repeated movements of their arms, hands and fingers. Therapists try to make these movements into games to keep [...]

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